Figure 1. (a) NF-κB and (b) IRF activity in human macrophages in response to Mtb lysate stimulation from different lineages: Indo-Oceanic (lineage 1), HN878 (lineage 2, also known as East Asian), East-African-Indian (lineage 3), CDC1551 (lineage 4), and M. bovis. Lipoarabinomannan (LAM) and lipopolysaccharide (LPS) were used as controls. Untreated: lighter color. IL-26 monomer-treated: medium color. IL-26 dimer-treated: darker color. *P < 0.05 (Wilcoxon matched-pairs signed rank test). Data of three independent experiments. IRF: interferon regulatory factor; Mtb: Mycobacterium tuberculosis; NF-κB: nuclear factor kappa B.
